1. recurrent infection
2. sleep apnoea
3. tumour growth
Friday, October 3, 2008
Friday, September 12, 2008
Steroids
1. Examples: Methylprednisolone, betamethasone, dexamethasone, hydrocortisone, cortisone acetate, triamcinolone, deflazacort
2. Side-effects:
2. Side-effects:
- diabetes
- osteoporosis
- AVN of femoral head
- euphoria + other paranioa; also depression
- proximal myopathy --> muscle wasting
- peptic ulceration
- Cushing's
- suppression of growth in children
- adrenal atrophy (long-term). Important to avoid abrupt after long term use (>3 wks) as: 1) acute adrenal insufficiency; then 2) hypotension; then 3) death!
- Atypical infections
- chickenpox with atypical features (i.e. rash not a feature e.g. pneumonia, hepatitis, DIC)
Thursday, September 11, 2008
Case Study
- 66 yr old gentleman
- 2 yrs hx of unsteadiness on feet - shuffle when walking
- noticed weakness in the legs
- loss of balance
- increase in freqeuncy of micturition
- reduced in memory
- in recent 2-3 months, starts to develop tremors in hands when try to do something
- loss of bladder control
- symptoms get worst
- no significant finding in PMHx, DHx, FHx and SHx
- Normal pressure hydrocephalus(NMH) aka adult onset hydrocephalus
- ataxia
- dementia
- incontinence
- MRI
- ventriculo-peritoneal shunt
Leg Claudication
Neurogenic (nerve root compression)
- pain on exertion (walking a distance/climbing up hills or stairs)
- relieved by bending forward
- sensory symptoms ie pins and needles
- pain on exertion (walking a distance/climbing up hills or stairs)
- relieved by hanging legs over side of bed (at night)
- no sensory symptoms
Saturday, September 6, 2008
Parkinson's disease
Pathology
Triad of classical symptoms
- Idiopathic, degenerative
- progressive death of dopaminergic neurone in substantia nigra
- relative excess of acetylcholine
Triad of classical symptoms
- akinesia/bradykinesia (usually upper body)
- resting tremor (asymmetrical, abolished by movement)
- rigidity (asymmetrical)
- lack of arm swing
- short step
- Parkinsonian face (flat face?)
- postural instability
- dementia
- bradykinesia: do alternate supination/pronation tap
- rigidity: check tone, remember to distract the patient
- therapeutic trial of levodopa (walking test before and after taking levodopa)
- education and support
- physiotherapy, occupational therapy, speech and language therapy
- drugs (levodopa, sinemet, selegiline)
- essential tremor
- Alzheimer
- drug
- Lewy body dementia
- multisystem atrophy
- progressive supranuclear palsy
Tuesday, September 2, 2008
Headache
- commonest headache - tension headache
- commonest debilitating headache - migraine
- commonest brain tumour - brain mets
what would you do when you get the headache?
- lie down and sleep - migraine
- keep on doing activity as before - tension headache
- bang head with hand/on the wall - cluster headache
Tuesday, August 26, 2008
Acute asthma in children
Assessment of severity
- respiratory rate
- work on breathing (accessory muscles, recession/tug)
- oxygen saturation
- nebulized oxygen
- nebulized salbutamol
- ipratropium bromide (only in acute severe episode)
- steroid (given PO, but if the child is vomitting or in comatose, can use IV)
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